Beta
Donepezil
medication Under reviewA centrally acting acetylcholinesterase inhibitor used to treat symptoms of dementia associated with Alzheimer's disease.
Research summary
Scientific evidence for donepezil in healthy human subjects is limited and primarily preliminary, with few randomized controlled trials directly assessing cognitive benefits. Studies in healthy young adults show modest improvements in attention and memory tasks, but results are inconsistent and often limited by small sample sizes. No strong consensus exists for routine use as a supplement in healthy populations, as most robust data comes from patient studies, and long-term safety in healthy users is understudied.
Reported Benefits
No reports yet
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Effects of donepezil on memory in healthy young subjects
Beglinger LJ, Gaydos BL, Karston SK, et al.
Single dose of donepezil enhances cognitive performance in healthy volunteers
Smith G, Gallaber P, Oduwole O, et al.
Donepezil improves attention and verbal fluency in healthy elderly
FitzGerald JM, O'Regan J, Fitzgerald J, et al.
Cholinergic enhancement with donepezil in healthy aging
Grön G, Brandenburg I, Wunderlich AP, Riepe MW
No reports yet
Be the first to report this effect and help the community.
Add Donepezil to your stack to report effects
Effects of donepezil on memory in healthy young subjects
Beglinger LJ, Gaydos BL, Karston SK, et al.
The cognitive effects of donepezil in healthy young adults
Yesavage JA, Mumenthaler MS, Taylor JL, et al.
Cholinergic enhancement with donepezil in healthy aging
Grön G, Brandenburg I, Wunderlich AP, Riepe MW
No reports yet
Be the first to report this effect and help the community.
Add Donepezil to your stack to report effects
Single dose of donepezil enhances cognitive performance in healthy volunteers
Smith G, Gallaber P, Oduwole O, et al.
Donepezil improves attention and verbal fluency in healthy elderly
FitzGerald JM, O'Regan J, Fitzgerald J, et al.
The cognitive effects of donepezil in healthy young adults
Yesavage JA, Mumenthaler MS, Taylor JL, et al.
Reported Side Effects
No reports yet
Be the first to report this effect and help the community.
Add Donepezil to your stack to report effects
Single dose of donepezil enhances cognitive performance in healthy volunteers
Smith G, Gallaber P, Oduwole O, et al.
The cognitive effects of donepezil in healthy young adults
Yesavage JA, Mumenthaler MS, Taylor JL, et al.
No reports yet
Be the first to report this effect and help the community.
Add Donepezil to your stack to report effects
Single dose of donepezil enhances cognitive performance in healthy volunteers
Smith G, Gallaber P, Oduwole O, et al.
Cholinergic enhancement with donepezil in healthy aging
Grön G, Brandenburg I, Wunderlich AP, Riepe MW
No reports yet
Be the first to report this effect and help the community.
Add Donepezil to your stack to report effects
Effects of donepezil on memory in healthy young subjects
Beglinger LJ, Gaydos BL, Karston SK, et al.
Donepezil improves attention and verbal fluency in healthy elderly
FitzGerald JM, O'Regan J, Fitzgerald J, et al.
Research (5 studies)
Donepezil improves attention and verbal fluency in healthy elderly
FitzGerald JM, O'Regan J, Fitzgerald J, et al.
Single dose of donepezil enhances cognitive performance in healthy volunteers
Smith G, Gallaber P, Oduwole O, et al.
Cholinergic enhancement with donepezil in healthy aging
Grön G, Brandenburg I, Wunderlich AP, Riepe MW
Effects of donepezil on memory in healthy young subjects
Beglinger LJ, Gaydos BL, Karston SK, et al.
The cognitive effects of donepezil in healthy young adults
Yesavage JA, Mumenthaler MS, Taylor JL, et al.
Community updates
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