Research Hub

A study published in Nature Medicine found that older adults taking a daily multivitamin showed slower biological aging—approximately 4 months less than those who didn't take supplements.

Research revealed that gut microbes produce short-chain fatty acids from dietary sugar, establishing a symbiotic relationship crucial to many body functions previously thought to depend solely on fiber.

Stanford Medicine experts report that while nearly three in five American adults take supplements, most offer no scientifically proven benefit, and some can be harmful, with better absorption from whole foods.

Analysis of 2,877 centenarians found approximately 10-12% used dietary supplements, with calcium, protein, and multivitamins being most common, suggesting modest supplement use in longevity populations.

A study published in Nature Medicine found that older adults taking a daily multivitamin showed slower biological aging—approximately 4 months less than those who didn't take supplements.

Higher levels of the minerals copper and manganese in pregnant women were associated with lower blood pressure and reduced risk of developing hypertension decades later.

A study in Nature Medicine found that older adults taking a daily multivitamin, such as Centrum Silver, experienced slower biological aging, equivalent to about four months less aging compared to placebo over three years. This suggests potential clinical benefits for physical and cognitive function in aging populations.

The NIH Office of Dietary Supplements released a strategic plan outlining expanded research on vitamins, minerals, and supplements, fostering federal collaboration for evidence-based health insights applicable to public nutrition.

A randomized clinical trial tests five food supplements rich in fibers (psyllium, glucomannan, inulin), choline, and herbal extracts (artichoke, cumin, peppermint) combined with diet restriction in overweight adults, targeting body fat, visceral fat, lipids, and inflammation over eight weeks.

Higher copper and manganese levels in pregnant women were associated with lower blood pressure and reduced hypertension risk decades later, based on long-term cohort data. This highlights prenatal mineral status for cardiovascular health implications.

A study found older adults taking daily multivitamins showed slower biological aging, about 4 months less than placebo, measured by DNA methylation clocks. Published in Nature Medicine with practical implications for longevity in seniors.

NIH Office of Dietary Supplements releases key research advances in vitamins, minerals, and supplements, informing practical health strategies. Includes strategic plan for 2025-2029 research.

Randomized trial tests fiber blends (plantain, glucomannan), herbals (artichoke, cumin), vitamins/minerals with calorie restriction on body fat, lipids, inflammation in overweight adults over 8 weeks. Outcomes include fat loss and metabolic improvements.

Higher copper and manganese in pregnant women associated with lower blood pressure and reduced hypertension risk decades later. Key for maternal nutrition and cardiovascular health.

A Nature Medicine study found that older adults taking daily multivitamins experienced biological aging approximately 4 months slower than non-users, suggesting potential longevity benefits.

Recent research reveals that high doses of antioxidants, often considered harmless, may have transgenerational effects, with male mice studies showing potential impacts on offspring.

Analysis of 2,877 Chinese centenarians found 10.7% of females and 12.3% of males used dietary supplements, primarily calcium, protein, and multivitamins, with median use duration of 2-10 years.

Higher levels of copper and manganese minerals in pregnant women were associated with lower blood pressure and reduced risk of hypertension decades later in offspring.

Research published in Nature Medicine found that older adults taking daily multivitamins biologically aged 3-5 months slower than those who did not take supplements.

The NIH Office of Dietary Supplements published its Strategic Plan for 2025–2029, outlining priorities for advancing dietary supplement research and federal collaboration.

Analysis of over 200,000 individuals followed for more than 30 years showed higher intake of plant-based oils like soybean, canola, and olive oil associated with reduced mortality risk.

During 2017–2018, 57.6% of US adults aged 20+ used any dietary supplement, with higher use among women and increasing with age; multivitamins, vitamin D, and omega-3 were most common.

Researchers at Mass General Brigham found that older adults taking a daily multivitamin exhibited slower biological aging, equivalent to about 4 months less aging compared to those who did not take supplements.

Combining omega-3 (1g+ for women), vitamin D, and strength training slowed biological aging by 3.8 months and reduced prefrailty by 40%, with omega-3 dose effects varying by gender.

Higher copper and manganese levels in pregnant women associated with reduced blood pressure and hypertension risk decades later in midlife.

A randomized double-blind trial tests five fiber-rich supplements with diet restriction in overweight adults, targeting improvements in lipids, blood pressure, inflammation, and body fat over eight weeks.

The AREDS2 formula, replacing beta-carotene with lutein and zeaxanthin, reduces lung cancer risk and is more effective at slowing age-related macular degeneration progression.

A randomized trial in the COSMOS study found that daily multivitamins for two years slowed epigenetic aging by 0.113-0.214 years per year on biological clocks in adults around age 70, with benefits for inflammation and cognition. This could reduce cancer risk by 3-7% over 10 years.

Large study of 200,000+ people over 30 years shows higher plant-based oils (soybean, canola, olive) intake linked to better health vs. butter.

Older adults taking a daily multivitamin showed slower biological aging, about four months less than those who didn't, per Mass General Brigham study published in Nature Medicine.

Research from Mass General Brigham found older adults on daily multivitamins biologically aged slower by roughly 4 months compared to non-users.

Researchers at Mass General Brigham found that older adults taking a daily multivitamin showed approximately 4 months slower biological aging compared to those who did not take supplements.

A new clinical trial suggests a 5-day fasting-mimicking diet could offer real relief for Crohn's disease, a condition that has long lacked clear dietary guidance.

Research revealed that gut microbes produce short-chain fatty acids from dietary sugar, establishing a symbiotic relationship crucial to many body functions beyond fiber fermentation.

The FDA approved Foundayo, a GLP-1 receptor agonist tablet for weight management, marking the fastest approval of a new molecular entity since 2002 and the first NME under the Commissioner's National Priority Voucher program.

A 2026 review in Nutrients journal found vitamin D influences over 1,000 genes and is essential for skeletal health and may shape immune, metabolic, and neurodevelopmental pathways during early life, though non-skeletal benefits need stronger human evidence.

Researchers at Mass General Brigham found that older adults taking a daily multivitamin showed slower biological aging—approximately 4 months less than those who didn't take supplements.

A large NIH clinical trial found that omega-3 fatty acid supplements from fish oil did not slow cognitive decline in older persons, despite some observational evidence suggesting dietary omega-3s may protect brain health.

Stanford Medicine nutrition experts report that while nearly 60% of American adults take supplements, most offer no scientifically proven benefit and some can be harmful, with the supplement market largely unregulated compared to pharmaceuticals.

A sweeping review of nearly 20 studies found healthier diets linked to fewer depressive symptoms in teens, while poor eating habits associated with increased mental health concerns.

A Nature Medicine study found older adults taking daily multivitamins showed slower biological aging—approximately four months less than those who didn't take supplements.

A comprehensive review in Nutrients found vitamin D is essential for skeletal health and may influence immune, metabolic, and neurodevelopmental pathways during early life, though non-skeletal benefits in humans need stronger evidence.

2026 is anticipated to be the most impactful year for dietary supplements since the introduction of GMPs, with significant regulatory changes expected for the industry.

FDA held a public meeting on March 27, 2026 to explore the regulatory scope of dietary supplement ingredients including proteins, enzymes, and microbials under DSHEA, with comment deadline of April 27, 2026.

Increased daylight in summer supports serotonin production and vitamin D synthesis, improving mood and energy levels, while longer daylight hours regulate circadian rhythms and encourage outdoor activity and exercise.

The Office of Dietary Supplement (ODS) presented virtual seminars on dietary supplement research and related topics as part of the 2025-2026 seminar series.