Mastic Gum

In asymptomatic H. pylori–positive adults, short-term administration of mastic gum alone produced only modest and non-sustained reductions in bacterial load and did not achieve reliable eradication compared with standard triple therapy. The intervention was well tolerated and did not cause significant side effects in these otherwise healthy carriers.

In adults with mildly elevated cholesterol but otherwise healthy, supplementation with mastic gum for several weeks led to modest reductions in total and LDL cholesterol and improvements in certain inflammatory markers, without significant changes in liver function tests. The supplement was well tolerated and no serious adverse effects were recorded.

In adults with functional dyspepsia and no major comorbidities, mastic gum at a daily dose of 1050 mg for three weeks significantly improved global dyspepsia scores and specific symptoms such as stomach pain and heartburn compared with placebo. The supplement was well tolerated, with no serious adverse events reported in this otherwise healthy cohort.

In adults with mildly elevated cholesterol but otherwise healthy, supplementation with mastic gum for several weeks led to modest reductions in total and LDL cholesterol and improvements in certain inflammatory markers, without significant changes in liver function tests. The supplement was well tolerated and no serious adverse effects were recorded.

This narrative review summarizes clinical trials and experimental studies on Chios mastic gum, concluding that it exhibits anti-inflammatory, antioxidant, antimicrobial, and wound-healing effects, with human data suggesting benefits for functional dyspepsia, inflammatory bowel disease, oral health, and wound healing. The authors note that mastic is generally safe in clinical use but emphasize the need for larger, longer-term trials, especially in healthy populations.

This narrative review summarizes clinical trials and experimental studies on Chios mastic gum, concluding that it exhibits anti-inflammatory, antioxidant, antimicrobial, and wound-healing effects, with human data suggesting benefits for functional dyspepsia, inflammatory bowel disease, oral health, and wound healing. The authors note that mastic is generally safe in clinical use but emphasize the need for larger, longer-term trials, especially in healthy populations.

In adults with functional dyspepsia and no major comorbidities, mastic gum at a daily dose of 1050 mg for three weeks significantly improved global dyspepsia scores and specific symptoms such as stomach pain and heartburn compared with placebo. The supplement was well tolerated, with no serious adverse events reported in this otherwise healthy cohort.

In adults with functional dyspepsia and no major comorbidities, mastic gum at a daily dose of 1050 mg for three weeks significantly improved global dyspepsia scores and specific symptoms such as stomach pain and heartburn compared with placebo. The supplement was well tolerated, with no serious adverse events reported in this otherwise healthy cohort.

This narrative review summarizes clinical trials and experimental studies on Chios mastic gum, concluding that it exhibits anti-inflammatory, antioxidant, antimicrobial, and wound-healing effects, with human data suggesting benefits for functional dyspepsia, inflammatory bowel disease, oral health, and wound healing. The authors note that mastic is generally safe in clinical use but emphasize the need for larger, longer-term trials, especially in healthy populations.

In a small group of healthy volunteers, short-term oral intake of mastic gum increased serum total antioxidant capacity compared with baseline, suggesting a systemic antioxidant effect. No clinically significant adverse events were observed during the study period.