Measles, Mumps, Rubella, and Varicella Vaccine

In a cross-sectional study of healthy health care workers, prior vaccination with measles, mumps, rubella, and varicella vaccines was strongly associated with varicella seropositivity and high immunity levels, supporting the effectiveness of vaccination in maintaining protective antibody responses.

In this large cohort study of healthy children receiving their first dose of measles-containing vaccine, the combined MMRV product was associated with a higher rate of febrile seizures within 7–10 days compared with separate MMR and varicella vaccines, but the absolute risk remained low and no long-term adverse neurologic outcomes were identified.

In a cross-sectional study of healthy health care workers, prior vaccination with measles, mumps, rubella, and varicella vaccines was strongly associated with varicella seropositivity and high immunity levels, supporting the effectiveness of vaccination in maintaining protective antibody responses.

In a cross-sectional study of healthy health care workers, prior vaccination with measles, mumps, rubella, and varicella vaccines was strongly associated with varicella seropositivity and high immunity levels, supporting the effectiveness of vaccination in maintaining protective antibody responses.

This case-control study in healthy pediatric vaccine recipients estimated the risk of immune thrombocytopenic purpura after MMR vaccination at roughly 1 per 30,000–40,000 doses, with most cases resolving and no fatalities reported. The authors concluded that this rare adverse event does not outweigh the benefits of routine vaccination.

This meta-analysis of cohort and case-control studies involving over 1.25 million children found no causal association between measles-mumps-rubella vaccination and autism spectrum disorders. The results provide strong evidence that MMR vaccination in healthy children does not increase autism risk.