Beta
Nattokinase
supplement Under reviewA fibrinolytic enzyme extracted from the traditional Japanese food natto, often used to support cardiovascular health.
Research May Be Outdated
This habit has been flagged for a research update. Recent studies may not be included.
Research summary
Scientific evidence from human studies, primarily randomized controlled trials and meta-analyses, indicates that nattokinase supplementation can modestly reduce systolic and diastolic blood pressure in healthy adults and those with elevated levels. Higher doses around 10,800 FU daily appear more effective for reducing arterial plaque size, triglycerides, and LDL cholesterol compared to lower doses, with benefits more pronounced in certain subgroups like obese or active individuals. While fibrinolytic and antithrombotic effects are supported, lipid improvements are inconsistent at lower doses, and overall evidence is promising but limited by small study numbers and calls for larger trials.
Reported Benefits
No reports yet
Be the first to report this effect and help the community.
Add Nattokinase to your stack to report effects
Nattokinase Prevents the Progression of Atherosclerosis by Reducing Arterial Plaque Size: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ren NN, Chen H, Li Y, McGowan E, Lin Y
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Chen H, McGowan EM, Ren N, et al.
No reports yet
Be the first to report this effect and help the community.
Add Nattokinase to your stack to report effects
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Chen H, McGowan EM, Ren N, et al.
Nattokinase and Red Yeast Rice Combination for Cardiovascular Health: A Randomized, Double-Blinded, Placebo-Controlled Trial
Chen WT, et al.
No reports yet
Be the first to report this effect and help the community.
Add Nattokinase to your stack to report effects
Nattokinase Prevents the Progression of Atherosclerosis by Reducing Arterial Plaque Size: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ren NN, Chen H, Li Y, McGowan E, Lin Y
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Coronary artery disease or other cardiac conditions
Nattokinase Prevents the Progression of Atherosclerosis by Reducing Arterial Plaque Size: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ren NN, Chen H, Li Y, McGowan E, Lin Y
Elevated LDL cholesterol or total cholesterol levels
Nattokinase Prevents the Progression of Atherosclerosis by Reducing Arterial Plaque Size: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ren NN, Chen H, Li Y, McGowan E, Lin Y
Research (4 studies)
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Chen H, McGowan EM, Ren N, et al.
Nattokinase and Red Yeast Rice Combination for Cardiovascular Health: A Randomized, Double-Blinded, Placebo-Controlled Trial
Chen WT, et al.
Nattokinase Prevents the Progression of Atherosclerosis by Reducing Arterial Plaque Size: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ren NN, Chen H, Li Y, McGowan E, Lin Y
Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases.
Weng Y, Yao J, Sparks S, Wang KY
Community updates
No updates yet for this supplement.
Be the first to share your experience!