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Nizatidine
medication Under reviewAn H2 receptor antagonist used to treat gastroesophageal reflux disease and peptic ulcer disease by reducing stomach acid production.
Research summary
Human studies on nizatidine are extensive and focus primarily on acid-related gastrointestinal conditions. Randomized, double-blind, placebo-controlled trials in adults and adolescents show that standard prescription doses (150 mg twice daily or 300 mg at bedtime) improve endoscopically diagnosed esophagitis, heal erosive and ulcerative esophagitis, and reduce GERD symptoms while decreasing the need for supplemental antacids. Over-the-counter dose studies (75 mg) in generally healthy adults with episodic heartburn demonstrate faster and more reliable symptom relief compared with placebo in at-home, real-world conditions. Safety data from large clinical trial programs and post-marketing experience indicate that nizatidine is generally well tolerated, with adverse events overall similar to placebo in short-term use. Common side effects include mild gastrointestinal complaints and occasionally central nervous system symptoms such as headache or insomnia. Rare but clinically important events such as elevated liver enzymes, hepatitis, jaundice, anemia, thrombocytopenia, and sexual side effects (decreased libido, impotence, gynecomastia) have been reported, mostly in patient populations rather than specifically in healthy volunteers. Bioequivalence and pharmacokinetic studies in healthy adults confirm predictable absorption and support generic formulations. There is no strong evidence of antiandrogenic effects in controlled studies.
Reported Benefits
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Bioequivalence Study of Nizatidine Capsules 300 mg of Dr. Reddy's Laboratories Limited and Axid Capsules 300 mg of Braintree Laboratories Inc. in Healthy Human Subjects
Dr. Reddy's Laboratories Ltd.
Effectiveness and safety of nizatidine, 75 mg, for the relief of episodic heartburn.
Nwokolo CU, Smith PM, Gervais P, Preston T, et al.
Nizatidine gastroesophageal reflux disease trials in adolescents and adults
Axid (nizatidine) prescribing information, Braintree Laboratories
No reports yet
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Bioequivalence Study of Nizatidine Capsules 300 mg of Dr. Reddy's Laboratories Limited and Axid Capsules 300 mg of Braintree Laboratories Inc. in Healthy Human Subjects
Dr. Reddy's Laboratories Ltd.
Nizatidine gastroesophageal reflux disease trials in adolescents and adults
Axid (nizatidine) prescribing information, Braintree Laboratories
No reports yet
Be the first to report this effect and help the community.
Add Nizatidine to your stack to report effects
Bioequivalence Study of Nizatidine Capsules 300 mg of Dr. Reddy's Laboratories Limited and Axid Capsules 300 mg of Braintree Laboratories Inc. in Healthy Human Subjects
Dr. Reddy's Laboratories Ltd.
Effectiveness and safety of nizatidine, 75 mg, for the relief of episodic heartburn.
Nwokolo CU, Smith PM, Gervais P, Preston T, et al.
Reported Side Effects
No reports yet
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Multicenter, Double-Blind, Placebo-Controlled Crossover Study of Nizatidine in Gastroesophageal Reflux Disease
Cohen S, Booth GH, Bianchine JR, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Gastroesophageal reflux disease — chronic acid reflux
Bioequivalence Study of Nizatidine Capsules 300 mg of Dr. Reddy's Laboratories Limited and Axid Capsules 300 mg of Braintree Laboratories Inc. in Healthy Human Subjects
Dr. Reddy's Laboratories Ltd.
Research (4 studies)
Bioequivalence Study of Nizatidine Capsules 300 mg of Dr. Reddy's Laboratories Limited and Axid Capsules 300 mg of Braintree Laboratories Inc. in Healthy Human Subjects
Dr. Reddy's Laboratories Ltd.
Nizatidine gastroesophageal reflux disease trials in adolescents and adults
Axid (nizatidine) prescribing information, Braintree Laboratories
Effectiveness and safety of nizatidine, 75 mg, for the relief of episodic heartburn.
Nwokolo CU, Smith PM, Gervais P, Preston T, et al.
Multicenter, Double-Blind, Placebo-Controlled Crossover Study of Nizatidine in Gastroesophageal Reflux Disease
Cohen S, Booth GH, Bianchine JR, et al.
Community updates
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