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Phenindione
medication Under reviewAn oral anticoagulant medication that functions as a Vitamin K antagonist to prevent blood clot formation.
Research summary
Human research on phenindione is almost entirely in the context of therapeutic anticoagulation rather than use as a general supplement in healthy individuals. Comparative studies from the mid‑20th century evaluated phenindione against other vitamin K antagonists and found broadly similar anticoagulant efficacy and ability to achieve therapeutic prothrombin inhibition when appropriately dosed and monitored. Detailed mechanistic work in human subjects described multiphasic effects on the coagulation system, confirming that phenindione reduces activity of vitamin K–dependent clotting factors and alters various stages of the clotting cascade. There are no controlled trials in healthy volunteers evaluating phenindione for general health optimization, performance, longevity or other typical supplement‑style outcomes. Instead, the evidence base focuses on its pharmacodynamics, dosing strategies, and comparative safety and efficacy as a prescription anticoagulant in patients with cardiovascular and thromboembolic disease. Because of significant bleeding risk and potential for hypersensitivity and other adverse reactions, phenindione is considered a prescription drug rather than a nutraceutical supplement, and its use in otherwise healthy people purely for preventive or enhancement purposes is not supported by evidence.
Reported Benefits
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Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
No reports yet
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Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
No reports yet
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Add Phenindione to your stack to report effects
Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
Reported Side Effects
No reports yet
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Clinical Experience with Phenindione in Anticoagulant Therapy
Various
Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Irregular heart rhythm that increases stroke risk
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
Coronary artery disease or other cardiac conditions
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
Clinical Experience with Phenindione in Anticoagulant Therapy
Various
Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
Research (3 studies)
Phenindione in the Prophylaxis of Systemic Embolisation in Rheumatic Heart Disease and Atrial Fibrillation
Various
Clinical Experience with Phenindione in Anticoagulant Therapy
Various
A comparative study of four prothrombinopenic anticoagulant drugs. I. Properties.
Wright IS, Heiman M, Feitelberg S
Community updates
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