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Rabeprazole
medication Under reviewA proton pump inhibitor (PPI) used to treat conditions involving excessive stomach acid, such as GERD and peptic ulcers.
Research summary
Human research on rabeprazole is extensive, but most studies focus on patients with acid-related disorders rather than healthy volunteers. In healthy subjects, controlled pharmacokinetic and pharmacodynamic studies show predictable acid suppression, high protein binding, and a favorable short-term safety profile without clinically meaningful effects on major organ systems or endocrine function at standard doses. These studies underpin its routine clinical use and inform dose selection. Overall, the research consensus is that rabeprazole is an effective acid-suppressing agent with good tolerability when used at typical therapeutic doses. Short-term studies in healthy volunteers generally report mild and transient adverse effects such as headache or gastrointestinal discomfort. Long-term safety data largely come from patient populations rather than healthy subjects, but do not indicate major systemic toxicity at standard doses. As a result, rabeprazole is regarded as a well-characterized PPI suitable for clinical use when prescribed appropriately.
Reported Benefits
No reports yet
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ACIPHEX (rabeprazole sodium) prescribing information: clinical pharmacology and safety in healthy male volunteers
Eisai Inc.
Real-world prospective observational study evaluating rabeprazole DDR formulation in GERD
Bhatia SJ et al.
Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.
Rabeprazole Study Group
No reports yet
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Rabeprazole in healthy volunteers: plasma protein binding and pharmacokinetics
Various
ACIPHEX (rabeprazole sodium) prescribing information: clinical pharmacology and safety in healthy male volunteers
Eisai Inc.
Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.
Rabeprazole Study Group
No reports yet
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Add Rabeprazole to your stack to report effects
ACIPHEX (rabeprazole sodium) prescribing information: clinical pharmacology and safety in healthy male volunteers
Eisai Inc.
Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.
Rabeprazole Study Group
Reported Side Effects
No reports yet
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A study of rabeprazole and pantoprazole on stomach acid and drug levels in healthy volunteers
AstraZeneca and collaborators
No reports yet
Be the first to report this effect and help the community.
Add Rabeprazole to your stack to report effects
A study of rabeprazole and pantoprazole on stomach acid and drug levels in healthy volunteers
AstraZeneca and collaborators
No reports yet
Be the first to report this effect and help the community.
Add Rabeprazole to your stack to report effects
A study of rabeprazole and pantoprazole on stomach acid and drug levels in healthy volunteers
AstraZeneca and collaborators
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Gastroesophageal reflux disease — chronic acid reflux
Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.
Rabeprazole Study Group
ACIPHEX (rabeprazole sodium) prescribing information: clinical pharmacology and safety in healthy male volunteers
Eisai Inc.
Rabeprazole in healthy volunteers: plasma protein binding and pharmacokinetics
Various
Research (5 studies)
Real-world prospective observational study evaluating rabeprazole DDR formulation in GERD
Bhatia SJ et al.
A study of rabeprazole and pantoprazole on stomach acid and drug levels in healthy volunteers
AstraZeneca and collaborators
Rabeprazole in healthy volunteers: plasma protein binding and pharmacokinetics
Various
ACIPHEX (rabeprazole sodium) prescribing information: clinical pharmacology and safety in healthy male volunteers
Eisai Inc.
Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.
Rabeprazole Study Group
Community updates
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