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Spironolactone
medication Under reviewA potassium-sparing diuretic medication used to treat fluid retention, high blood pressure, and various hormonal conditions.
Research summary
Human research on spironolactone is extensive for approved cardiovascular indications, but in healthy or relatively healthy populations the most relevant evidence concerns off‑label dermatologic use and emerging neuropsychiatric applications. Randomized, placebo‑controlled trials in women with acne vulgaris show that oral spironolactone at doses of 50–100 mg daily improves inflammatory acne lesions and global acne severity with acceptable tolerability, supporting its role as an effective antiandrogenic therapy for female acne. Large observational analyses have also examined spironolactone use in otherwise healthy young women and girls, documenting substantial growth in prescribing over the past two decades, mainly driven by dermatologic indications. An exploratory human study suggests that spironolactone exposure is associated with reduced hazardous alcohol consumption in adults with heavy drinking patterns, raising interest in its potential as a pharmacotherapy for alcohol use disorder. Overall, the research consensus supports spironolactone as a hormone‑modulating drug with clear benefits for certain conditions, but its use is medication‑level rather than a general wellness supplement, and safety considerations such as hyperkalemia, endocrine effects, and potential drug interactions are central.
Reported Benefits
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Oral spironolactone for acne vulgaris in females: a clinical review and evidence synthesis
Thompson A, et al.
No reports yet
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Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent models and human data
Satta R, et al.
Reported Side Effects
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Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
No reports yet
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Add Spironolactone to your stack to report effects
Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
No reports yet
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Add Spironolactone to your stack to report effects
Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
No reports yet
Be the first to report this effect and help the community.
Add Spironolactone to your stack to report effects
Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
No reports yet
Be the first to report this effect and help the community.
Add Spironolactone to your stack to report effects
Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Skin condition causing pimples, blackheads, and cysts
Oral spironolactone for acne vulgaris in females: a clinical review and evidence synthesis
Thompson A, et al.
Trends in the Proportion of Young Women and Girls Prescribed Spironolactone.
Dieleman JL, et al.
Research (4 studies)
Oral spironolactone for acne vulgaris in females: a clinical review and evidence synthesis
Thompson A, et al.
Trends in the Proportion of Young Women and Girls Prescribed Spironolactone.
Dieleman JL, et al.
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent models and human data
Satta R, et al.
Adverse effect profile of spironolactone: a clinical experience in adult patients
Ahmed A, et al.
Community updates
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