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Trazodone
medicationAntidepressant commonly prescribed off-label for insomnia at low doses (25-100mg). Helps with sleep maintenance without next-day grogginess.
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Pharmacokinetics of single oral dose trazodone: a randomized, two-period, cross-over trial in healthy, adult, human volunteers under fed condition.
RCT
Not specified in available data
Frontiers in Pharmacology
2015
n=47
Strong Evidence
Single oral dose of trazodone was well tolerated in 47 healthy volunteers under fed conditions, with bioequivalence confirmed between test and reference products and no serious adverse events.
Bioequivalence Study of Trazodone: Single Oral Dose under Fasting Conditions in Healthy Human Subjects
RCT
Not specified in excerpt
Journal of Pharmacology and Clinical Toxicology
2016
n=51
Strong Evidence
Trazodone single dose under fasting conditions was well tolerated in 51 healthy subjects, with only three mild adverse events reported and no clinically significant changes in safety parameters.
Research (2 studies)
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