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Vitamin K2 MK-4
supplementMenaquinone-4, animal-derived with shorter half-life. Requires multiple daily doses. Used in Japanese bone health studies.
Reported Benefits
Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
Not specified in source
Low-dose MK-4 supplementation for 6-12 months improved bone quality in postmenopausal women by significantly decreasing serum undercarboxylated osteocalcin and pentosidine concentrations, with no significant decrease in bone mineral density loss compared to controls.
MK-4 supplementation maintains strong bones and reduces fracture risk in postmenopausal women
Cockayne et al.
Meta-analysis of 19 randomized controlled clinical trials involving 6,759 volunteers demonstrated that MK-4 at 45 mg daily in divided doses resulted in statistically significant 60% fewer vertebral fractures and 76% fewer nonvertebral fractures compared to placebo.
MK-4 bone density and fracture reduction in postmenopausal women
Not specified in source
Systematic review and meta-analysis of 10 randomized controlled clinical trials with 5,413 women ages 45-81 showed that MK-4 maintains strong bones as indicated by 62% fewer fractures in volunteers.
The efficacy of the traditional Chinese medicine Jia Wei Niu Bang Zi granule combined with methotrexate in treating active rheumatoid arthritis: A multicenter, randomized, double-blinded controlled clinical trial.
Not specified in source
A larger multicenter randomized double-blinded controlled clinical trial with 213 postmenopausal women (mean age 64) showed bone density increased by 1.2% in the lumbar spine and 2.7% in the hip after twelve months, with MK-4 being well tolerated and safe.
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Research (4 studies)
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