Beta
Ca-AKG
supplementCalcium Alpha-Ketoglutarate plays a crucial role in cellular energy production.
Reported Benefits
Evaluation of the Efficacy of Calcium Alpha-Ketoglutarate (AKG-Ca) in Supporting Healthy Aging
Not specified in source
An ongoing randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 45-75 years evaluating CaAKG supplementation for 12 weeks, with primary outcomes measuring biological aging via PhenoAge and secondary outcomes including physical performance, inflammatory markers, glucose and lipid metabolism, and quality of life.
Alpha-ketoglutarate supplementation and Biological Age in middle-aged and older adults
Not specified in source
A randomized controlled trial recruiting 120 middle-aged participants with elevated DNA methylation age compared to chronological age to test whether Ca-AKG supplementation can reduce biological age and improve muscle strength, cardiovascular function, and aerobic capacity over 9 months.
The Effect of Ca-AKG on Biological Age: A Clinical Trial
Not specified in source
A clinical study of 42 healthy adults using TruAge DNA methylation testing found that Ca-AKG supplementation combined with gender-specific vitamins produced an average reduction of 7.96 years in biological age after approximately 7 months of use, with males experiencing an 8.44-year reduction and females a 6.98-year reduction.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test.
Ponce de Leon Health Team
Analysis of 42 self-reported healthy individuals taking Rejuvant (sustained-release Ca-AKG plus vitamins) for 4-10 months showed a statistically significant average reduction of 7.96 years in epigenetic age, from 0.35 years younger to 8.31 years younger than chronological age.
Bodybuilding supplement promotes healthy aging and extends life span in mice
Azar Asadi Shahmirzadi and colleagues
Preclinical research demonstrated that AKG-fed mice showed improved physical appearance, scored 40% better on frailty tests measuring 31 physiological attributes including hair color, hearing, gait, and grip strength, and female mice lived 8-20% longer than control mice.
The Anti-Aging & Longevity Benefits of Alpha-Ketoglutarate
NOVOS Labs
A long-term real-world study found that sustained-release Ca-AKG at a dose similar to one NOVOS Core sachet was linked to a nearly 8-year reduction in biological age measured from DNA in saliva after several months of daily use.
Alpha-ketoglutarate supplementation and Biological Age in middle-aged and older adults
Not specified in source
A randomized controlled trial recruiting 120 middle-aged participants with elevated DNA methylation age compared to chronological age to test whether Ca-AKG supplementation can reduce biological age and improve muscle strength, cardiovascular function, and aerobic capacity over 9 months.
Bodybuilding supplement promotes healthy aging and extends life span in mice
Azar Asadi Shahmirzadi and colleagues
Preclinical research demonstrated that AKG-fed mice showed improved physical appearance, scored 40% better on frailty tests measuring 31 physiological attributes including hair color, hearing, gait, and grip strength, and female mice lived 8-20% longer than control mice.
Bodybuilding supplement promotes healthy aging and extends life span in mice
Azar Asadi Shahmirzadi and colleagues
Preclinical research demonstrated that AKG-fed mice showed improved physical appearance, scored 40% better on frailty tests measuring 31 physiological attributes including hair color, hearing, gait, and grip strength, and female mice lived 8-20% longer than control mice.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test.
Ponce de Leon Health Team
Analysis of 42 self-reported healthy individuals taking Rejuvant (sustained-release Ca-AKG plus vitamins) for 4-10 months showed a statistically significant average reduction of 7.96 years in epigenetic age, from 0.35 years younger to 8.31 years younger than chronological age.
The Effect of Ca-AKG on Biological Age: A Clinical Trial
Not specified in source
A clinical study of 42 healthy adults using TruAge DNA methylation testing found that Ca-AKG supplementation combined with gender-specific vitamins produced an average reduction of 7.96 years in biological age after approximately 7 months of use, with males experiencing an 8.44-year reduction and females a 6.98-year reduction.
Alpha-ketoglutarate supplementation and Biological Age in middle-aged and older adults
Not specified in source
A randomized controlled trial recruiting 120 middle-aged participants with elevated DNA methylation age compared to chronological age to test whether Ca-AKG supplementation can reduce biological age and improve muscle strength, cardiovascular function, and aerobic capacity over 9 months.
Evaluation of the Efficacy of Calcium Alpha-Ketoglutarate (AKG-Ca) in Supporting Healthy Aging
Not specified in source
An ongoing randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 45-75 years evaluating CaAKG supplementation for 12 weeks, with primary outcomes measuring biological aging via PhenoAge and secondary outcomes including physical performance, inflammatory markers, glucose and lipid metabolism, and quality of life.
Alpha-ketoglutarate supplementation and Biological Age in middle-aged and older adults
Not specified in source
A randomized controlled trial recruiting 120 middle-aged participants with elevated DNA methylation age compared to chronological age to test whether Ca-AKG supplementation can reduce biological age and improve muscle strength, cardiovascular function, and aerobic capacity over 9 months.
Alpha-ketoglutarate supplementation and Biological Age in middle-aged and older adults
Not specified in source
A randomized controlled trial recruiting 120 middle-aged participants with elevated DNA methylation age compared to chronological age to test whether Ca-AKG supplementation can reduce biological age and improve muscle strength, cardiovascular function, and aerobic capacity over 9 months.
The Effect of Ca-AKG on Biological Age: A Clinical Trial
Not specified in source
A clinical study of 42 healthy adults using TruAge DNA methylation testing found that Ca-AKG supplementation combined with gender-specific vitamins produced an average reduction of 7.96 years in biological age after approximately 7 months of use, with males experiencing an 8.44-year reduction and females a 6.98-year reduction.
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Research (6 studies)
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