Folate (Methylfolate)
supplementL-methylfolate is the active form of folate (vitamin B9) that supports methylation and cardiovascular health.
Reported Benefits
Effect of L-methylfolate on Depressive Symptoms in Patients with MTHFR Mutations
Unknown
Patients, including some without diagnosed depression but with MTHFR mutations, showed a 25% reduction in depressive symptoms after L-methylfolate treatment, with greater improvements in those aged 41-50.
Assessing Effects of l-Methylfolate in Depression Management: Results of 2 Randomized Placebo-Controlled Trials and 1 Open-Label Study
Papakostas GI, et al.
Patients reported significant improvements in mood and functioning with l-methylfolate augmentation, though primarily in those with depression; high satisfaction and compliance noted across groups.
No side effects tracked yet
No side effects have been reported by studies or users for this habit yet.
Related health conditions
Research showing how this habit affects specific health conditions. Always consult healthcare professionals.
May Help With
Major depressive disorder or persistent depressive symptoms
Effect of L-methylfolate on Depressive Symptoms in Patients with MTHFR Mutations
Unknown
Patients, including some without diagnosed depression but with MTHFR mutations, showed a 25% reduction in depressive symptoms after L-methylfolate treatment, with greater improvements in those aged 41-50.
Assessing Effects of l-Methylfolate in Depression Management: Results of 2 Randomized Placebo-Controlled Trials and 1 Open-Label Study
Papakostas GI, et al.
Patients reported significant improvements in mood and functioning with l-methylfolate augmentation, though primarily in those with depression; high satisfaction and compliance noted across groups.
Research (2 studies)
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